{"id":57,"date":"2011-02-16T00:00:06","date_gmt":"2011-02-15T15:00:06","guid":{"rendered":"https:\/\/dousoukai.site\/yukyokai\/?p=57"},"modified":"2020-09-09T17:35:58","modified_gmt":"2020-09-09T08:35:58","slug":"%e5%ae%ae%e5%ae%b6%e9%9a%86%e6%ac%a1%e5%8d%9a%e5%a3%ab%e3%81%ae%e6%a5%ad%e7%b8%be%e3%82%92%e8%ae%83%e3%81%88%e3%82%8b%e9%9b%86%e3%81%84-%e5%b0%8f%e4%be%bf%e3%81%ae%e4%b8%ad%e3%81%ab%e5%91%bd","status":"publish","type":"post","link":"https:\/\/dousoukai.site\/yukyokai\/57\/","title":{"rendered":"\u5bae\u5bb6\u9686\u6b21\u535a\u58eb\u306e\u696d\u7e3e\u3092\u8b83\u3048\u308b\u96c6\u3044 \u201c\u5c0f\u4fbf\u306e\u4e2d\u306b\u547d\u304c\u3042\u3063\u305f\u201d"},"content":{"rendered":"

\u3000\u5e74\u672b\u3082\u62bc\u3057\u8a70\u307e\u3063\u305f\u6628\u5e7412\u670828\u65e518\u6642\u3088\u308a\u30a6\u30a7\u30eb\u30cd\u30b9\u30b9\u30af\u30a8\u30a23F(\u307f\u3086\u304d\u306e\u91cc\u3001\u718a\u672c\u5e02\u5fa1\u5e78\u7b1b\u7530\u753a)\u3067\u83ca\u6c60\u990a\u751f\u5712\u30fb\u7af9\u718a\u5ba3\u5b5d\u540d\u8a89\u5712\u9577\u306e\u304a\u4e16\u8a71\u3067\u3001\u5bae\u5bb6\u9686\u6b21\u535a\u58eb\u306e\u696d\u7e3e\u3092\u8b83\u3048\u308b\u96c6\u3044\u304c\u958b\u50ac\u3055\u308c\u305f\u3002<\/p>\n

    \n
  1. \u958b\u4f1a\u306e\u6328\u62f6<\/li>\n<\/ol>\n

    \u5148\u305a\u7af9\u718a\u540d\u8a89\u5712\u9577\u3088\u308a\u81ea\u3089\u3082\u6240\u5c5e\u3057\u3066\u3044\u305f\u718a\u672c\u5927\u5b66\u533b\u5b66\u90e8\u7b2c2\u5185\u79d1(\u65e7\u6cb3\u5317\u5185\u79d1)\u5bae\u5bb6\u30b0\u30eb\u30fc\u30d7(5\u7814)\u306e\u7dcf\u52e216\u540d\u3068\u6545\u4eba5\u540d\u3092\u4ee3\u8868\u3057\u3066\u958b\u4f1a\u306e\u6328\u62f6\u304c\u3042\u308a\u3001\u300c\u4eca\u65e5\u3053\u3053\u306b\u718a\u672c\u770c\u77e5\u4e8b(\u51fa\u5f35\u4e2d)\u3001\u718a\u672c\u5e02\u9577\u59cb\u3081\u5404\u754c\u3001\u5404\u5c64\u306e\u65b9\u3005\u306b\u3054\u81e8\u5e2d\u3044\u305f\u3060\u304d\u3001\u30a8\u30ea\u30b9\u30ed\u30dd\u30a8\u30c1\u30f3(EPO)\u306b\u81ea\u3089\u306e\u547d\u3092\u7e4b\u3044\u3067\u304a\u3089\u308c\u308b\u900f\u6790\u60a3\u8005\u306e\u65b9\u3005\u3068\u305d\u306e\u3054\u5bb6\u65cf\u3068\u5171\u306b\u3001\u5bae\u5bb6\u535a\u58eb\u306e\u696d\u7e3e\u3092\u305f\u305f\u3048\u308b\u4f1a\u3092\u50ac\u3059\u3053\u3068\u304c\u51fa\u6765\u307e\u3059\u3053\u3068\u306f\u3001\u8aa0\u306b\u559c\u3073\u306b\u582a\u3048\u307e\u305b\u3093\u3002\u305d\u3057\u3066\u5bae\u5bb6\u535a\u58eb\u306b\u95a2\u3059\u308b\u8a18\u4e8b\u3092\u5916\u56fd\u306e\u8457\u540d\u306a\u30b8\u30e3\u30fc\u30ca\u30ea\u30b9\u30c8\u306e\u30ec\u30dd\u30fc\u30c8\u3092\u901a\u3057\u3066\u65e5\u672c\u5168\u56fd\u306b\u5831\u3058\u3089\u308c\u305f\u671d\u65e5\u65b0\u805e\u51fa\u7248\u90e8(1)\u3001\u305d\u306e\u4ed6\u88fd\u85ac\u3001\u5831\u9053\u5404\u793e\u306b\u5bae\u5bb6\u6c0f\u306e\u696d\u7e3e\u3092\u7d39\u4ecb\u3057\u3066\u6234\u3044\u305f\u3053\u3068\u3092\u5fc3\u304b\u3089\u611f\u8b1d\u7533\u3057\u4e0a\u3052\u307e\u3059\u3002\u300d\u3068\u8ff0\u3079\u305f\u3002
    \n(2)\u3001\u305d\u306e\u5f8c\u907a\u4f1d\u5b50\u30af\u30ed\u30fc\u30cb\u30f3\u30b0\u306e\u65b9\u6cd5\u3092\u7528\u3044EPO\u306e\u88fd\u54c1\u5316\u3078\u306e\u9053\u304c\u958b\u304b\u308c\u305f(3)\u3001\u3053\u306e\u5206\u91ce\u3067\u4e16\u754c\u4e2d\u304b\u3089\u6700\u3082\u6ce8\u76ee\u3055\u308c\u308b\u5b58\u5728\u3068\u306a\u3063\u305f\u3002\u65e5\u672c\u306e\u4e2d\u5916\u88fd\u85ac\u3068\u5171\u540c\u3067\u65e5\u672c\u3067\u3082\u88fd\u54c1\u5316\u304c\u9032\u307f\u3001\u4eca\u65e5\u306b\u81f3\u3063\u3066\u3044\u308b\u3002\u6c0f\u306f\u5e30\u56fd\u5f8c\u3001\u6674\u8015\u96e8\u8aad\u306e\u751f\u6d3b\u3067\u3042\u3063\u305f\u304c\u3001\u4e0d\u5e78\u306b\u3082\u5589\u982d\u306e\u60aa\u6027\u816b\u760d\u306b\u5192\u3055\u308c\u306b\u8a00\u8449\u3092\u5931\u3063\u305f\u3002<\/p>\n

      \n
    1. EPO\u306e\u6b74\u53f2\u3068\u5bae\u5bb6\u7814\u7a76\u5ba4\u306e\u6d3b\u52d5<\/li>\n<\/ol>\n

      \u718a\u672c\u7b2c1\u75c5\u9662\u306e\u6cb3\u5317\u8aa0\u7dcf\u9662\u9577\u306e\u8a73\u7d30\u306a\u8aac\u660e\u304c\u3042\u3063\u305f\u3002\u59cb\u3081\u7c73\u56fd\u306eGoldwasser\u7b49\u304c\u8ca7\u8840\u306b\u3057\u305f\u7f8a1000\u982d\u304b\u3089 \u308f\u305a\u304b3mg\u306eEPO\u3092\u62bd\u51fa\u3057\u305f\u306e\u304c1971\u5e74(4)\u3001\u540c\u5e74\u518d\u751f\u4e0d\u826f\u6027\u8ca7\u8840\u60a3\u8005\u306e\u5c3f\u306b\u6ce8\u76ee\u3057\u3001\u6700\u521d\u306e\u5831\u544a\u3092\u718a\u5927\u533b\u5b66\u90e8\u306e\u82f1\u6587\u30b8\u30e3\u30fc\u30ca\u30ebKumamoto Medical Journal\u3067\u767a\u8868(2)\u30a2\u30e1\u30ea\u30ab\u306b\u6e21\u308a2,55\u30c8\u30f3\u306e\u518d\u751f\u4e0d\u826f\u6027\u8ca7\u8840\u306e\u60a3\u8005\u5c3f\u304b\u308910mg\u306e\u6d3b\u6027\u6bd4\u306e\u9ad8\u3044EPO\u3092\u62bd\u51fa\u3057\u305f\u306e\u304c1977\u5e74(3)\u3002
      \n\u3053\u306e\u7cbe\u88fdEPO\u3092\u7528\u3044\u3066\u907a\u4f1d\u5b50\u30af\u30ed\u30fc\u30cb\u30f3\u30b0\u306b\u6210\u529f\u3057\u305f\u306e\u304c1985\u5e74\u3067\u3057\u305f\u3002
      \n\u3053\u306e\u907a\u4f1d\u5b50\u5de5\u5b66\u306b\u3088\u308a\u30d2\u30c8\u30ea\u30b3\u30f3\u30d3\u30ca\u30f3\u30c8(rHuEPO)\u306e\u5927\u91cf\u751f\u7523\u304c\u53ef\u80fd\u3068\u306a\u308a\u3001\u3053\u306eEPO\u88fd\u5264\u306f\u4eca\u4e16\u754c\u3067200\u4e07\u4eba\u3001\u65e5\u672c\u3067\u308230\u4e07\u4eba\u306e\u60a3\u8005\u3055\u3093\u306e\u547d\u3092\u652f\u3048\u3066\u3044\u307e\u3059\u53ef\u80fd\u306b\u306a\u3063\u305f\u3002
      \n\u305d\u306e\u7814\u7a76\u8005\u3053\u305d\u3053\u305d\u718a\u672c\u5e02\u57ce\u5c71\u534a\u7530\u751f\u307e\u308c\u306e\u5bae\u5bb6\u9686\u6b21\u6c0f\u3067\u3042\u308b\u3002
      \n\u6c0f\u306f\u718a\u5927\u533b\u5b66\u90e8\u306b\u9032\u5b66\u3001\u5927\u5b66\u9662\u3067\u751f\u5316\u5b66\u3092\u5b66\u3073\u3001\u305d\u306e\u5f8c\u7b2c2\u5185\u79d1\u3067\u81e8\u5e8a\u306b\u5f93\u4e8b\u3057\u3001\u7570\u5e38\u8840\u8272\u7d20\u75c7\u306a\u3069\u306e\u7814\u7a76\u6307\u5c0e\u3092\u884c\u3063\u3066\u3044\u305f\u3002\u814e\u4e0d\u5168\u306e\u6cbb\u7642\u306f\u8840\u6db2\u900f\u6790\u304c\u5c0e\u5165\u3055\u308c\u3066\u304b\u3089\u683c\u6bb5\u306b\u9032\u6b69\u3057\u305f\u304c\u7684\u78ba\u306a\u8ca7\u8840\u306e\u6cbb\u7642\u6cd5\u306fEPO\u88fd\u5264\u304c\u767b\u5834\u3059\u308b\u307e\u3067\u306f\u306a\u304b\u3063\u305f\u3002\u6162\u6027\u814e\u4e0d\u5168\u306e\u8ca7\u8840\u4f8b\u3067\u306fEPO\u7523\u5236\u80fd\u304c\u6975\u5ea6\u306b\u4f4e\u4e0b\u3057\u3066\u3044\u307e\u3059\u304c\u3001EPO\u3092\u6295\u4e0e\u3059\u308b\u3068\u3001\u5e72\u5929\u306e\u6148\u96e8\u306e\u3088\u3046\u306b\u7d20\u6674\u3089\u3057\u3044\u52b9\u679c\u304c\u8a8d\u3081\u3089\u308c\u307e\u3059\u3002
      \nEPO\u306f\u54fa\u4e73\u985e\u306b\u3068\u3063\u3066\u8d64\u8840\u7403\u306e\u7523\u751f\u3092\u6052\u5e38\u7684\u306b\u306b\u8abf\u7bc0\u3059\u308b\u751f\u7406\u7684\u30db\u30eb\u30e2\u30f3\u3067\u3059\u3002\u66f4\u306bEPO\u306f\u9020\u8840\u4f5c\u7528\u3068\u7570\u306a\u308b\u81d3\u5668\u4fdd\u8b77\u4f5c\u7528\u304c\u6ce8\u76ee\u3055\u308c\u3066\u304d\u3066\u3001\u4eca\u5f8c\u66f4\u306b\u767a\u5c55\u3059\u308b\u53ef\u80fd\u6027\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u767a\u5c55\u306e\u5143\u306b\u306a\u3063\u305f\u5bae\u5bb6\u9686\u6b21\u535a\u58eb\u306e\u696d\u7e3e\u306f\u4e16\u754c\u4eba\u985e\u306b\u5bfe\u3059\u308b\u5049\u5927\u306a\u8ca2\u732e\u3067\u3042\u308a\u3001\u3053\u308c\u306f\u718a\u672c\u5927\u5b66\u533b\u5b66\u90e8\u540c\u7a93\u751f\u3068\u3057\u3066\u3001\u307e\u305f\u65e5\u672c\u4eba\u3068\u3057\u3066\u306e\u8a87\u308a\u3067\u3042\u308a\u3001\u5bae\u5bb6\u9686\u6b21\u535a\u58eb\u306e\u529f\u7e3e\u306f\u6c38\u9060\u306b\u8f1d\u304f\u91d1\u5b57\u5854\u3067\u3042\u308a\u307e\u3059\u3002<\/p>\n

        \n
      1. \u5bae\u5bb6\u535a\u58eb\u3078\u306e\u8b1d\u8f9e:\u60a3\u8005\u3055\u3093\u3092\u4ee3\u8868\u3057\u3066\u5927\u725f\u7530\u5e02\u306e\u5742\u4e95\u5149\u5247\u3055\u3093\u304c\u8ff0\u3079\u3089\u308c\u305f\u3002<\/li>\n
      2. \u5bae\u5bb6\u535a\u58eb\u304b\u3089\u718a\u5927\u533b\u5b66\u90e8\u306e\u82e5\u304d\u7814\u7a76\u8005\u3078\u306e\u30e1\u30c3\u30bb\u30fc\u30b8\u300c\u533b\u5b66\u306e\u7814\u7a76\u306f\u60a3\u8005\u306e\u305f\u3081\u306b\u3042\u308a\u3001\u540d\u8a89\u3084\u7d4c\u6e08\u7684\u76ee\u7684\u3067\u306f\u306a\u3044\u3002\u7814\u7a76\u7d50\u679c\u306b\u3064\u3044\u3066\u306f\u6b63\u76f4\u3067\u3042\u308c\u300d\u3068\u5bb6\u65cf\u3092\u901a\u3058\u3066\u4f1d\u3048\u3089\u308c\u305f\u3002<\/li>\n
      3. \u795d\u8f9e:\u718a\u672c\u5e02\u9577\u304b\u3089\u795d\u8f9e\u304c\u306e\u3079\u3089\u308c\u3001\u7d9a\u3044\u3066\u718a\u5927\u533b\u5b66\u90e8\u540c\u7a93\u4f1a(\u718a\u674f\u4f1a)\u795e\u539f\u4f1a\u9577\u304cOECD\u52a0\u76df28\u30ab\u56fd\u306e\u653f\u5e9c\u304c\u9ad8\u7b49\u6559\u80b2\u6a5f\u95a2\u3078\u306e\u516c\u8ca1\u653f\u652f\u51fa\u8cbb\u7528\u306f28\u30ab\u56fd\u306e\u5e73\u57471.1%\u306b\u5bfe\u3057\u65e5\u672c\u306f0.5%\u3067\u30d3\u30ea\u3067\u3059\u3002\u6211\u3005\u718a\u5927\u533b\u5b66\u90e8\u540c\u7a93\u4f1a\u306f12\u5e74\u524d\u306b\u80a5\u5f8c\u533b\u80b2\u632f\u8208\u4f1a\u3092\u4f5c\u308a\u3001\u5404\u4f1a\u54e1\u3084\u4e00\u822c\u4eba\u304b\u3089\u8cb4\u91cd\u306a\u6d44\u8ca1\u306e\u5bc4\u9644\u3092\u53d7\u3051\u3001\u533b\u5b66\u306e\u767a\u5c55\u3068\u770c\u6c11\u306e\u5065\u5eb7\u3092\u5ff5\u3058\u3066\u8272\u3005\u306e\u652f\u63f4\u4e8b\u696d\u306b\u3092\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u53bb\u5e741\u67084\u65e5\u306b\u770c\u4e0b\u7b2c1\u53f7\u306e\u516c\u76ca\u8ca1\u56e3\u6cd5\u4eba\u306b\u8a8d\u5b9a\u3055\u308c\u3001\u533b\u5b66\u6559\u80b2\u3001\u7814\u7a76\u306e\u52a9\u6210\u306a\u3069\u3092\u884c\u3044\u3001\u718a\u65e5\u306e\u30a2\u30ec\u30f3\u30b8\u3084\u80a5\u5f8c\u533b\u80b2\u587e\u306a\u3069\u3092\u884c\u3044\u770c\u6c11\u306e\u5065\u5eb7\u5897\u9032\u3092\u5fd7\u3057\u3066\u3044\u307e\u3059\u306e\u3067\u770c\u6c11\u306b\u3082\u77e5\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u5927\u5b78\u306b\u3044\u308b\u3068\u6642\u3005\u4eca\u65e5\u306e\u30a8\u30ea\u30b9\u30ed\u30dd\u30a8\u30c1\u30f3\u306e\u3088\u3046\u306a\u4e16\u754c\u7684\u767a\u898b\u304c\u5831\u3058\u3089\u308c\u3066\u975e\u5e38\u306b\u611f\u6fc0\u3059\u308b\u6a5f\u4f1a\u304c\u3042\u308b\u306e\u304c\u4e00\u756a\u5b09\u3057\u3044\u3067\u3059\u3068\u795d\u8f9e\u3092\u8ff0\u3079\u305f\u3002<\/li>\n
      4. \u5bae\u5bb6\u535a\u58eb\u306b\u8a18\u5ff5\u54c1\u8d08\u5448\u304c\u884c\u308f\u308c\u3001\u5148\u751f\u306e\u529f\u7e3e\u306f\u5916\u56fd\u3067\u306f\u975e\u5e38\u306b\u9ad8\u304f\u8a55\u4fa1\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u65e5\u672c\u3067\u3082\u3082\u3063\u3068\u77e5\u3089\u3057\u3081\u308b\u5fc5\u8981\u304c\u3042\u308b\u3068\u5f37\u8abf\u3057\u9589\u4f1a\u3057\u305f\u3002<\/li>\n
      5. \u61c7\u89aa\u5915\u98df\u4f1a<\/li>\n<\/ol>\n

        \u7d9a\u3044\u3066\u4f1a\u5834\u30921\u968e\u7530\u5712\u30ad\u30c3\u30c1\u30f3\u306b\u79fb\u3057\u30a2\u30eb\u30b3\u30fc\u30eb\u7121\u3057\u3001\u4f1a\u8cbb900\u5186\u306e\u81ea\u7136\u98df\u30d0\u30a4\u30ad\u30f3\u30b0\u30d8\u30eb\u30b7\u30fc\u30e1\u30cb\u30e5\u30fc\u306e\u5915\u98df\u4f1a\u304c\u958b\u304b\u308c\u7d42\u4e86\u3057\u305f\u3002<\/p>\n

        \u53c2\u8003\u6587\u732e
        \n(1)\u30e1\u30ea\u30eb\u30fb\u30b0\u30fc\u30ba\u30ca\u30fc\u8457\u30a2\u30e1\u30ea\u30ab\u533b\u85ac\u54c1\u7814\u7a76\u958b\u767a\u306e\u88cf\u5074\u3002\u300c\u65b0\u85ac1\u3064\u306b1000\u5104\u5186!?\u3002\u6771\u4eac\u85ac\u79d1\u5927\u5b66\u533b\u85ac\u60c5\u5831\u7814\u7a76\u79d1\u8a33:\u671d\u65e5\u65b0\u805e\u51fa\u7248\u30002009
        \n(2)Kaneko,F.Miyake,T.et al.Urinary erythropoetin !1,Preparation of crude erythropoietin and its biological activity.Kumamoto Medical J.\u300024,95,l971.
        \n(3)Miyake, T. Kung.-H,and Goldwasser,E.Purification of human erythropoietin .
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        \n(4)Jacobs,etal:Nature.818,806,1985\/Lin,et.al.:Proc.Natl.Acade.d.Sci.USA,82.7580,1985.<\/p>\n","protected":false},"excerpt":{"rendered":"

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